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This fall, the Forbeck Foundation celebrates a year of groundbreaking discussions, from new SAB Chair Kimryn Rathmell's reflection on two decades of progress against once-"undruggable" cancer targets, to a spring Forums season that tackled aging's link to cancer risk and the mysteries of cellular plasticity. The issue welcomes three new Scientific Advisory Board members and six new Forbeck Scholars, while celebrating the ripple effects of past research, including a promising new therapeutic vulnerability in kidney cancer and the maturation of once-uncharted work on the genome's "dark matter." Readers will also find a closer look at inherited cancer risk from SAB member Lucy Godley, highlights from the first-ever Forbeck Scholars meetup at AACR, and opportunities to get involved through the upcoming Hearts of Gold Blue Jean Ball and Walk the Lake for Kira Faith, alongside several new ways to support the Foundation's mission of scientific collaboration.

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