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This episode dives into an upcoming Scientific Forum, Next Generation Models of Cancer, happening this November in Pacific Grove, California. Our hosts unpack an interview our team recorded with the forum's co-chairs, Dr. Esra Akbay (UT Southwestern) and Dr. Mohamed Abazeed (Northwestern), on what they call the ecosystem of imperfection surrounding cancer research today: every lab tool, from mice to zebrafish to lab-grown tissue, gets something right and something wrong, and the real work is figuring out which one to trust for which question, especially as new cancer drugs demand better ways to test them.